Basically, if you mix kratom with wrong drugs may cause your muscles so relaxed, that you will suffocate, or get a cardiac. Also, it affects liver in a long time consumption Mixing kratom with certain drugs can be dangerous or even lethal due to potential interactions and enhanced side effects. Some of the most concerning substances to avoid combining with kratom include: Opioids: Mixing kratom with prescription opioids like oxycodone, hydrocodone, or morphine can significantly increase the