IME absolutely. 1-3.5ish grams I am clearly stimulated, obviously more and more intoxicated the higher the dose is, but 4-8g literally just makes my stomach hurt and gives me a migrane unless I add 2+ and just sleep it off. I can feel things happening, but the painkilling is duller along with everything else. I am stimulated but not enough to do stuff, sedated but not enough to just ride it, irritated and stuff, basically feels like WD without the runny nose.