That's true. Pointless taking for ateast 24-48 hours, otherwise you need to take astronomical doses and when your receptors are clear enough to be effected by the mratom., you will need to carry on using these.large doses. I remember the first.time I used kratom for sub withdrawal. It was around 10 years ago before krarom.was a big thing . Had read about it on a forum and purchased some expecting nothing to happen as seemed.too good to be true. I was rattling like a bitch and took around 7 gra