It depends on the situation. For instance if I want to come off opiates I'll take the Bali strain because it kills withdrawal symptoms without giving you the euphoric high. If I want a stimulating Kratom strain with the Euphoric high. I buy the Red Indo Maeng Da. I've only tried a few strains but these work best for I only stick with red strains because the green and white strains give me headaches, but they might work for you.